Nativo Lopez-Vigil is a national Chicano political leader and immigrant rights activist.

Lopez is the president of the Mexican American Political Association and the national director of the Hermandad Mexicana Latinoamericana, a community service and advocacy organization for Mexican and Latin American immigrants throughout the United States. Based in Southern California , his importance in Los Angeles politics has been compared by the Los Angeles Times to that of Al Sharpton in New York and Jesse Jackson in Chicago.

Lopez, born in Boyle Heights, Los Angeles, grew up in Norwalk, California. He became an activist in 1968, inspired by Bert Corona and Cesar Chavez. He organized student walk-outs from high schools in order to demonstrate for education reform. He was involved in successful efforts to win a large-scale amnesty for undocumented immigrants 1986, and in campaigns to allow them to obtain drivers' licenses in the 1990s.

Lopez was one of the organizers of the 2006 United States immigration reform protests, both the March 25, 2006 demonstration in Los Angeles, and the Great American Boycott on May 1, 2006, which mobilized over a million people in Los Angeles on each ocassion.

On April 13, 2006, Lopez appeared on Lou Dobbs' television show, where he argued that "illegal immigrant" is an offensively racist term on par with "N” word.

Lopez assisted in the foundation of the National Alliance for Immigrants' Rights, a group founded on similar positions on immigration. Lopez is one of the main spokespeople of the immigrant rights movement, nationally.

He supports open borders for commerce, capital, and labor, and immediate amnesty for all undocumented immigrants, and iron-clad labor protections for all workers, particularly immigrant workers, especially the right to organize a union of their choosing. In moving towards this goal, he has argued for a strategy of working-class mobilization, demonstrations, and strikes, and electoral politics and lobbying.